A 1-mg/kg per day increase in steroid dose was associated with a fold increase in risk of any SAAE. Conclusion: Most patients with primary proteinuric kidney disease treated with steroids experienced at least one SAAE. Steroid therapy increased risk of hypertension, diabetes, weight gain, short stature, fractures, and infections after adjusting for disease-related injectable-steroids.ml by: 3 26/05/ · These subjects developed hypercalcemia and renal failure with nephrocalcinosis while injecting veterinary grade vitamin D with estimated doses of >10 million IU annually. Of note was that the injections were not for vitamin D but for the silicone-like effect of the oily carrying medium that was used to add bulk to specific muscle groups However, large doses of any corticosteroid can demonstrate these effects, particularly if given for longer than brief periods. Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and/or renal dysfunction Corticosteroid use is associated with a high risk of SAEs in IgAN patients, especially those who are older, have hypertension, or impaired kidney failure steroid injections function. It's also likely that steroids have direct toxic effects on the kidneys. They can be given in several different ways, including: into a joint an intra-articular injection into a muscle an intramuscular injection into the spine an epidural injection into the blood an intravenous injection The injections normally take a few days to start working, although some work in a few hours. Actual Enrollment :. Ibuprofen is injecting steroids with insulin syringe no-no for anyone suffering from kidney disease - it's even a risk taken long term for those without kidney disease.